Development of fetal brain renin–angiotensin system and hypertension programmed in fetal origins

Fetal and Neonatal Immune System Development and Failure

ZUSAMEN-FASSUNG:  Die oben angefuerte Erlaeuterung und Dis­kussion umfasst (I)- normale Entwicklung ein­zelner Hauptkomponente des menschlichen Immunmechanismus, ( 2) Faktoren, die moegli­cherweise fetalen Immunsystem aktivieren, (3) Faktoren, welche die Entwicklung des Immun­systems stoeren koennen.  REFERENCES 

Fetal origins of obesity.

The worldwide epidemic of obesity continues unabated. Obesity is notoriously difficult to treat, and, thus, prevention is critical. A new paradigm for prevention, which evolved from the notion that environmental factors in utero may influence lifelong health, has emerged in recent years. A large number of epidemiological studies have demonstrated a direct relationship between birth weight and B...

Fetal Programming Alterations in Circulatory and Renal Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 in Fetal Programmed Hypertension

Antenatal betamethasone treatment is a widely accepted therapy to accelerate lung development and improve survival in preterm infants. However, there are reports that infants who receive antenatal glucocorticoids exhibit higher systolic blood pressure in their early adolescent years. We have developed an experimental model of programming whereby the offspring of pregnant sheep administered clin...

Fetal Origins and Parental Responses;

Fetal brain development in chimpanzees versus humans

chimpanzee, 34–35 weeks) [4], human neonates do have larger brains than chimpanzee neonates [2]. It has been suggested that the extraordinary brain enlargement in humans is due to unique features in the human pattern of brain development during both the prenatal and postnatal periods [1,2]. It has been argued that all primates conform to a 12% ratio of brain mass to body mass from the fetal per...